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Musculoskeletal & Anti-Inflammatory Effects GLP-1 receptors are present in: Chondrocytes Synovial tissues Macrophages Potential benefits include: Reduced inflammatory cytokines NF-B inhibition Reduced cartilage degradation Improvement in osteoarthritis inflammation The anti-inflammatory role of GLP-1 may become clinically important in rheumatologic and degenerative diseases

Sections were stained with hematoxylin and eosin (H&E) for general morphology

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[24-26] Berberine increases the quantity of the beneficial bacteria Akkermansia muciniphila in the gut

And when you lose weight fast without enough protein, your body doesnt only burn fat it burns muscle